Histone Deacetylase Inhibitor Enhances Recovery after AKI
نویسندگان
چکیده
منابع مشابه
Histone deacetylase inhibitor FR901228 enhances adenovirus infection of hematopoietic cells.
Adenovirus infection of hematopoietic cells frequently requires high virus concentrations and long incubation times to obtain moderate infection levels because these cells have low levels of Coxsackie and adenovirus receptor (CAR) and alpha(v) integrin. The effect of treatment with FR901228 (depsipeptide), a histone deacetylase inhibitor in phase 2 clinical trials, was studied in K562 cells, gr...
متن کاملHybrid Polar Histone Deacetylase Inhibitor Induces Apoptosis
Inhibitors of histone deacetylase (HDAC) have been shown to have both apoptotic and differentiating effects on various tumor cells. M-carboxycinnamic acid bishydroxamide (CBHA) is a recently developed hybrid polar compound structurally related to hexamethylene bisacetamide. CBHA is a potent inhibitor of HDAC activity. CBHA induces cellular growth arrest and differentiation in model tumor system...
متن کاملKy-2, a Histone Deacetylase Inhibitor, Enhances High-Salinity Stress Tolerance in Arabidopsis thaliana.
Adaptation to environmental stress requires genome-wide changes in gene expression. Histone modifications are involved in gene regulation, but the role of histone modifications under environmental stress is not well understood. To reveal the relationship between histone modification and environmental stress, we assessed the effects of inhibitors of histone modification enzymes during salinity s...
متن کاملThe histone deacetylase inhibitor valproic acid enhances acquisition, extinction, and reconsolidation of conditioned fear.
Histone modifications contribute to the epigenetic regulation of gene expression, a process now recognized to be important for the consolidation of long-term memory. Valproic acid (VPA), used for many years as an anticonvulsant and a mood stabilizer, has effects on learning and memory and enhances the extinction of conditioned fear through its function as a histone deacetylase inhibitor (HDAC)....
متن کاملThe histone deacetylase inhibitor FK228 preferentially enhances adenovirus transgene expression in malignant cells.
PURPOSE Efficient adenovirus infection requires coxsackie-adenovirus receptor (CAR) and alpha(v) integrin. Whereas many malignant cells express these proteins poorly, normal tissues, especially liver, express high levels and are susceptible to adenovirus infection. Our previous studies showed that treatment of cancer cell lines with low concentrations of the histone deacetylase inhibitor FK228 ...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2013
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2012111055